Although biomaterials coat implants such as ceramics, polymers, and metals, repeated movements of bearing surfaces produce wear debris. Aseptic loosening (no infection) has been responsible for more than 70% of hip revisions and over 44% of knee revisions. Periprosthetic inflammation is due to macrophage activation and response to implant byproducts which result in the activation of osteoclasts and osteolysis, leading to aseptic loosening. Although success rates reaching greater than 90% for total knee arthroplasty have been documented, over one million replacements each year are projected to fail after 15 to 25 years of use due to subtle inflammation. Examples of such surgical interventions include the total knee arthroplasty, which is projected to increase by 601% from 2005 to 2030. IntroductionĪs successful orthopedic surgical implants increase over the years, the vast immunological complications associated with them become imperative to understand. Inflammation articles Innate immune response articles Orthopedic implants articles Prosthetic debris articles Article Details 1.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |